i use a marshall JCM 900 head, marshall 1960's lead cabinet with boss/electro-harmonix pedals. love stomp boxes. setup for me is a breeze. takes me about 5 minutes. i run a pedal board with a 1 spot daisy chain.
i used to use a powered SKB board but it was HUGE, so i downsized. i had a rackmount amp..never got a good sound. i love my JCM900 tho. its tubed like a fender amp is so i have nice cleans, and still have that nice crunch. (i bought it that way, otherwise it would be tubed like it should be)
i dont use the effects loop either, i used to...but it became a hassle.
to each his own tho...