There are a few +6 cranks out there, but that's because of manufacturing problems. The geniuses at Vito's didn't understand that they only had to offset the pin 1.5mm to make a +3, instead they offset it 3mm, creating the +6.
But to answer your question, +4 is the biggest you can go, however it will need the cases to be trenched. You can have the 115mm connecting rod on any crankshaft, and it does not affect the length of the stroke, just moves that stroke 5mm further from the center of the crankshaft.